About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
ModelAngelo software expands cryo-EM toolkit with faster atomic model building and identification of novel proteins
Kiarash Jamali, a Ph.D. student in Sjors Scheres’ group in the LMB’s Structural Studies Division, has designed a new machine learning software capable of fast, accurate model building at atomic levels and identification of new proteins beyond previous capabilities.
Structure of γ-Tubulin Ring Complex provides insights into nucleation process behind microtubule formation
David Barford’s group, in the LMB’s Structural Studies Division, in collaboration with John Kilmartin in the LMB’s Cell Biology Division, have used electron cryo-tomography and sub-tomogram averaging to determine the structure of native γTuRC capping microtubules from extracted Spindle Pole Bodies.
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Latest News
- Marc North: new Head of IT
The LMB is delighted to announce Marc North as the new Head of the LMB’s Information Technology (IT) Support department. […]
- Emmanuel Derivery awarded the 2024 Hooke Medal
Emmanuel Derivery, Group Leader in the LMB’s Cell Biology Division, is the 2024 recipient of the British Society for Cell Biology’s Hooke Medal. […]
Latest Publications
- Illuminating the role of chaperones in spliceosome biogenesis and recycling.
Zhang, S.
Nat Struct Mol Biol [Epub ahead of print]. (25th April 2024) - CRISPR in Nucleic Acids Research: the sequel.
Sale, JE., Stoddard, BL.
Nucleic Acids Res 52(7): 3489-3492. (24th April 2024) - Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.
Wharton, T., Crawshay-Williams, F., Schober, T., Floto, RA., Spring, DR.
Angew Chem Int Ed Engl 63(18): e202402267. (24th April 2024) - Things you should learn in graduate school.
Hegde, RS.
Trends Cell Biol 34(4): 269-271. (23rd April 2024) - Confronting heterogeneity in cryogenic electron microscopy data: Innovative strategies and future perspectives with data-driven methods.
Kimanius, D., Schwab, J.
Curr Opin Struct Biol 86: 102815 [Epub ahead of print]. (23rd April 2024) - Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted isolates.
De, K., et al.
Proc Natl Acad Sci U S A 121(17): e2403206121. (23rd April 2024) - Aortic Stenosis and Renal Function: A Bidirectional Mendelian Randomization Analysis.
Ciofani, JL., Han, D., Allahwala, UK., Bhindi, R.
J Am Heart Assoc : e034102 [Epub ahead of print]. (19th April 2024)
See more Publications